Writings:

• How The Indian Ocean Oil Spill Could Impact Global Health“ on Forbes.com

• Could Drug-Resistant Bacteria Cause The Next Pandemic?” on Forbes.com

• Duke University’s Homme Hellinga Scandal: The Untold Story of How Students Risked their Careers to Fight a Cover-Up

• Be the Revolution You Want to See: Resisting Transactional Politics and Embracing Transformational Politics for Our Time

• The mental health crisis among graduate students is a result of academia's unsustainable pyramid scheme

Scientific Publications:

Skepper, C. K. … Metzger, L., et al. “Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.” J. Med Chem. 2020 Jul 23;63(14):7773-7816. doi: 10.1021/acs.jmedchem.0c00347. Epub 2020 Jul 7.

Reck, F. ... Metzger, L., et al. “IID572: A New Potentially Best-In-Class β-Lactamase Inhibitor.” ACS Infect Dis. 2019 Jul 12;5(7):1045-1051. doi: 10.1021/acsinfecdis.9b00031. Epub 2019 Mar 27.

Sawyer WS, Wang L, Uehara T, Tamrakar P, Prathapam R, Mostafavi M, Metzger L.E. 4th, Feng B, Baxter Rath CM. “Targeted lipopolysaccharide biosynthetic intermediate analysis with normal-phase liquid chromatography mass spectrometry.” PLoS One. 2019 Feb 8;14(2):e0211803. doi: 10.1371/journal.pone.0211803.

Dean, C.R. ... Metzger, L.E. 4th et al. “Mode of Action of the Monobactam LYS228 and Mechanisms Decreasing In Vitro Susceptibility in Escherichia coli and Klebsiella pneumoniae.” Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e01200-18. doi: 10.1128/AAC.01200-18. Print 2018 Oct.

Reck, F. ... Metzger, L. et al. “Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.” Bioorg Med Chem Lett. 2018 Feb 15;28(4):748-755. doi: 10.1016/ j.bmcl.2018.01.006. Epub 2018 Jan 4.

Wei JR, Richie DL, Mostafavi M, Metzger L.E. 4th, Rath CM, Sawyer WS, Takeoka KT, Dean CR. "LpxK Is Essential for Growth of Acinetobacter baumannii ATCC 19606: Relationship to Toxic Accumulation of Lipid A Pathway Intermediates." mSphere. 2017 Jul 26;2(4). pii: e00199-17. doi: 10.1128/mSphere.00199-17.

Dovala D, Rath CM, Hu Q, Sawyer WS, Shia S, Elling RA, Knapp MS, Metzger L.E. 4th. Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism. Proc Natl Acad Sci U. S. A. 2016 Oct 11;113(41):E6064-E6071. Epub 2016 Sep 28. PMID: 27681620

Dovala D, Sawyer WS, Rath CM, Metzger L.E. 4th. Rapid analysis of protein expression and solubility with the SpyTagSpyCatcher system. Protein Expr Purif. 2016 Jan;117:44-51. doi: 10.1016/j.pep.2015.09.021. Epub 2015 Sep 21. PMID: 26405011

Metzger LE 4th, Lee JK, Finer-Moore JS, Raetz CR, Stroud RM. “LpxI structures reveal how a lipid A precursor is synthesized.” Nat Struct Mol Biol. 2012 Nov;19(11):1132-8. doi: 10.1038/nsmb.2393.

• Research Highlight, Finkelstein, J. M., “Twistin’ the fat away.” Nature Chemical Biology, 8(950), 2012.

Metzger LE 4th, Raetz CR. “An alternative route for UDP-diacylglucosamine hydrolysis in bacterial lipid A biosynthesis.” Biochemistry. 2010 Aug 10;49(31):6715-26. doi: 10.1021/bi1008744.PMID: 20608695

Metzger LE 4th, Raetz CR. “Purification and characterization of the lipid A disaccharide synthase (LpxB) from Escherichia coli, a peripheral membrane protein.” Biochemistry. 2009 Dec 8;48(48):11559-71. doi: 10.1021/bi901750f. PMID: 19883124

Immormino RM, Metzger LE 4th, Reardon PN, Dollins DE, Blagg BS, Gewirth DT. Different poses for ligand and chaperone in inhibitor-bound Hsp90 and GRP94: implications for paralog-specific drug design. J Mol Biol. 2009 May 22;388(5):1033-42. doi: 10.1016/j.jmb.2009.03.071. Epub 2009 Apr 8. PMID: 19361515

Brown WM, Metzger LE, Barlow JP, Hunsaker LA, Deck LM, Royer RE, Vander Jagt DL. 17-beta- Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold. Chem Biol Interact. 2003 Feb 1;143-144:481-91. PMID: 12604234